Table 2. Drugs Used for Acute Migraine Therapy

TRADE NAME
(MANUFACTURER)
COMPOSITION
ROUTE AND DOSE
Cafergot tablets and suppositories
(Sandoz)
1 mg ergotamine tartrate
100 mg caffeine
2 mg ergotamine tartrate
100 mg caffeine
Orally: 2 tablets at onset; 1 additional tablet every 30 min if needed to maximum 6/attack, 10/wk;
Rectally: 1 suppository at onset, second in 1 hr if needed; maximum 2/attack, 4/w
Gynergen tablets
(Sandoz)
1.0 mg ergotamine tartrate 2 tablets orally at onset, 1/30 min to maximum 6/attack, 10/wk
Gynergen injection
(Sandoz)
0.5 mg/ml ergotamine tartrate 0.5 ml subcutaneously or IM at onset; repeat at 40 min; maximum 2 ml/wk
D.H.E. 45 injection 1.0 mg/ml dihydroergotamine 1 ml IM at onset, repeat every hour to total of 3 ml if needed; may be given IV 0.5 mg or 1.0 mg every 8 hrs
Ergotrate maleate tablets (Lilly) 0.2 mg ergonovine maleate 1 tablet at onset, 1 every hour to 6/attack
Wigraine tablets and suppositories
(Organon)
1.0 mg ergotamine tartrate
100 mg caffeine
0.1 mg belladonna
130 mg phenacetin
1 tablet at onset, 1 every hour to 6/attack
1-2 tablets or suppositories at onset with 1-2 after 15 min to maximum of 6/attack or 12/wk
Stadol NS
ADDICTING !
(Bristol-Myers Squibb)
1.0 mg butorphanol tartrate nasal spray 1.0 mg at onset;
1.0 mg in 60 - 90 min
Imitrex
(Glaxo)
6 mg sumatriptan

25 or 50 mg sumatriptan
1 subcutaneous injection at onset may repeat 1 hour
Oral tablets; 1 at onset, repeat in 2 hours if necessary. Maximum dose 300mg/d
Maxalt
(Merck )
Maxalt-MLT
10 mg oral tablets, 1 at onset, repeat in 2 hours if
necesary
One table on tongue, repeat in 2 hours if needed
Zomig
(AstraZeneca)
5 mg oral tablest, 1 at onset, repeat in 2 hours if necessary



 

 

Return to Student Lecture

 

                                                                 © eMEDMAN