Table 3. Preventive therapy for migraine Drug Daily oral dosage range Drug Daily oral dosage range BETA-BLOCKERS CALCIUM CHANNEL BLOCKERS Propranolol* 40-240 mg Verapamil 120-480 mg> Nadolol* 20-80 mg Diltiazem 90-180 mg Atenolol** 50-150 mg Nifedipine 30-120 mg Timolol* 20-60 mg SEROTONIN ANTAGONISTS/AGONISTS Metoprolol** 50-300 mg Cyproheptadine 4-8 mg TRICYCLIC ANTIDEPRESSANTS Methysergide 4-6 mg Amitriptyline 10-200 mg Methylergonovine 0.2 mg tid or qid Nortriptyline 10-150 mg MAO INHIBITORS Doxepin 10-200 mg Phenelzine 30-90 mg Imipramine 10-200 mg SEROTONIN-REUPTAKE INHIBITORS ANTICONVULSANTS Fluoxetine 10-30 mg Phenytoin 300-800 mg Trazodone 50-300 mg Carbamazepine 200-800 mg NSAIDs Divalproex sodium 250-1,500 mg Naproxen 550-1,100 mg (eg, 275 mg tid) Gabapentin 300-1800 mg Meclofenamat 100-400 mg (eg, 50 mg tid) ALPHA-ADRENERGIC BLOCKERS Flubiprofen 50-200 mg Clonidine 0.1 mg bid or tid Ibuprofen 300-1,200 mg KEY * Nonselective. ** Selective. MAO: Monamine oxidase. NSAIDs: Nonsteroidal anti-inflammatory drugs.