9.0: Headache associated with noncephalic infection
9.1: Viral infection
Individuals who suffer from fever that is associated with septicemia or infectious diseases often complain of dull, deeply situated headaches and aching of their eyeballs. The mechanism of such pain is not understood. Sutherland and Wolff (1940) have compared it to headaches produced by injections of histamine. Wolff (1955) noted cerebral vasodilation in experimental animals that had been given typhoid vaccine. He concluded that headaches associated with acute infections, sepsis, and bacteremia are primarily caused by the distention of intracranial arteries. Patients with diffuse viral infections not necessarily an aseptic meningitis will often suffer diffuse severe headache.
9.2: Bacterial infection
Systemic bacterial infection producing a septicemia may produce a diffuse deeply situated dull headache particularly referred to the retroorbital region. The exact mechanism is not well-known, but it appears to be due to dilatation of intracranial arteries secondary to the accompanying fever.
9.3: Headaches related to other infection
A variety of systemic infections include those producing fever, may produce headache even though the central nervous system is not invaded.

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