BOTOX 2002

BOTOX WEB INFO

B. Todd Troost, MD

HEADACHE

Clostridium botulinum Identified as cause of botulism

E. Schantz, et al

began purifying

botulinum toxin

type A

Medical use evaluation

Type A 900 kD

complex

purification

optimization

1700-1800

1944

1950-1960

1968

History


	Development of the first commercial botulinum neurotoxin product.
	•An interesting series of events led to the development of botulinum neurotoxin for therapeutic use.
		–Botulinum toxin was first identified in 1895 as the causative agent in the food borne illness known as botulism.
		–In the mid-1940s, botulinum toxin type A was purified and found to be a 900 kD protein complex.
		–About 20 years later, Dr. Scott began testing botulinum toxin type A in monkeys as a possible therapy for strabismus.
		–The FDA approved testing in human volunteers in the late 1970s.