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Relpax information: Studies
and References
Relpax (Eletriptan, Pfizer) is the newest triptan and is
believed to be more efficacious in comparative trials. The
three comparative studies ( Sandrini (1), Goadsby (2), Mathew
(3), refs below) show the following:
| Mathew Study |
Headache Response |
|
Pain Free at 2 hours |
|
24 Hour sustained response |
| |
One hour |
Two hour |
|
|
|
|
| Eletriptan 40mg |
34%* |
67%** |
|
36%* |
|
43%** |
| Sumatriptan 100mg |
27% |
59% |
|
27% |
|
34% |
| |
*p<0.01 |
**p<0.001 |
|
*p<0.0001 |
|
**p<0.0003 |
| |
|
|
|
|
|
| Sandrini Study |
Headache Response |
|
Pain Free at 2 hours |
|
24 Hour sustained response |
| |
One hour |
Two hour |
|
|
|
|
| Eletriptan 80mg |
37%* |
67%* |
|
37%* |
|
54%* |
| Eletriptan 40 mg |
30% |
64%* |
|
31%** |
|
50%* |
| Sumatriptan 100mg |
27% |
53% |
|
18% |
|
38% |
| Sumatriptan 50mg |
24% |
50% |
|
19% |
|
34% |
| |
*p0.05 vs. suma. 100mg |
*p0.05 vs. suma. 100mg |
|
*p<0.0005 vs. suma 100mg |
|
*p<0.0005 vs. suma 100mg |
| **p<0.05 vs. suma. 100mg |
**p0.05 vs. suma. 100mg |
| |
|
|
|
|
|
|
| Goadsby Study |
Headache Response |
|
Pain Free at 2 hours |
|
24 Hour sustained response |
| |
One hour |
Two hour |
|
|
|
|
| Eletriptan 80mg |
41%* |
77%* |
|
37%* |
|
No data |
| Eletriptan 40 mg |
38%* |
65% |
|
29% |
|
|
| Sumatriptan 100mg |
20% |
55% |
|
23% |
|
|
| |
*p<0.01 vs. suma. 100mg |
*p<0.01 vs. suma. 100mg |
|
*p<0.05 vs. suma. 100mg |
|
|
| |
|
|
|
|
|
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An argument has been put forth that the encapsulation of
sumatriptan had an effect on the trials, but other evidence
suggests that encapsulation had no effect on the outcome (4) and
that the sumatriptan results are quite comparable to efficacy
found in other sumatriptan trials.
(1) Sandrini G, Farkkila M, Burgess G, Forster E, Haughie S,
Eletriptan Steering Committee. Eletriptan vs sumatriptan: a
double-blind, placebo controlled, multiple migraine attack
study. Neurology 2002;59: 1210-1217.
(2) Goadsby PJ, Ferrari MD, Olesen J, et al. Eletriptan in acute
migraine: a double-blind, placebo-controlled comparison to
sumatriptan. Eletriptan Steering Committee. Neurology
200;54:156-163.
(3) Mathew NT, Schoenen J, Winner P, Muirhead N, Sikes CR.
Comparative efficacy of eletriptan 40 mg versus sumatriptan 100
mg. Headache 2003;43:214-222.
(4) Sandrini G, Farkkila M, Forster E. Eletriptan vs
sumatriptan: a double-blind, placebo-controlled, multiple
migraine attack study (letter) Neurology 2003;60:1222
These trials appear to show that Relpax (eletriptan) 40 mg
has superior efficacy compared to sumatriptan (Imitrex.) 100 mg.
Printable MS Word Document
Pfizer Relpax Page
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